Wine Information Council

Wine Information Council

In this study, the association between the consumption of specific alcoholic beverages and hip fractures was examined.

Data from the Nurses Health Study and from the Health Professionals Follow-Up Study were assessed and pointed toward a lower risk of fractures in moderate wine drinkers, especially among women who consumed red wine.

The researchers explained this observation by pointing out to the content of flavonoids in red wine which are potent antioxideants. It has indeed been shown that aging may lead to increased oxidative stress, which may in turn negatively affect the bone‘s mineral density.


Fung TT et al, Alcohol intake, specific alcoholic beverages, and risk of hip fractures in postmenopausal women and men age 50 and older, Am J Clin Nutr 2019;00:1-10.

For more information about this article, read the scientific abstract here.

A new study has shown that the resveratrol found in red wine demonstrates stress relieving effects in anxiety and depression. This could be due to the resveratrol’s ability to control an enzyme in the brain that is linked to stress …….

Resveratrol has been shown to have numerous beneficial properties on health and is found abundantly in the skins and seeds of berries and grapes. It is a natural  polyphenol found in red wine, which has numerous pharmacological properties including anti-stress and antidepressant-like abilities. The researchers explained that this polypenol specifically played a role in an enzyme (phosphodiesterase 4, PDE4) which is influenced by the stress hormone corticosterone. This finding was new in their study.

Cortisol or corticosterone is released in the body as a response to stress and excess stress can trigger excess release of the hormone that reaches the brain and leads to depression and anxiety. At present the treatment for depression and anxiety focuses on serotonin or noradrenaline – neurotransmitters in the brain.

For their study, the scientists used an animal model with mice on which they showed that the enzyme PDE4 in the brain was influenced by the excess cortisol released as a response to stress. This led to anxiety and depression related symptoms in the mice. It did so by lowering levels of a messenger molecule called cyclic adenosine monophosphate.

Normally, corticosterone regulates the body's response to stress. When there's too much stress, though, the large amounts of the hormone circulating in the brain lead to an excess of PDE4. This in turn physically alters the brain, causing the problems.

After administering resveratrol to the mice, the scientists found that the polyphenol could help reverse these negative effects and observed a neuroprotective effect in the brain by working against the damage caused by corticosterone. As a result, the mice appeared to be considerably less depressed and anxious upon being stressed. The polyphenol successfully inhibited the expression of PDE4.

Resveratrol may be an effective alternative to drugs for treating patients suffering from depression and anxiety disorders conclude the researchers. However, they warn that resveratrol’s beneficial effect does not translate into red wine consumption since excessive consumption of alcoholic beverages is associated with various health risks.

(The equivalent amount that was given to the test animals (1 mg of resveratrol per kg of body weight) would be approx. 88 bottles of red wine to be effective in an 90 kg man.

Zhu X et al, The antidepressant- and anxiolytic-like effects of resveratrol: Involvement of phosphodiesterase-4D inhibition, Neuropharmacology 153, 2019: 20-31.

For more information about this article, read the scientific abstract here.

A study evaluated the association between the amount and frequency of alcohol consumption and incident dementia in 53,311 older Japanese adults over a long follow-up period. A health checkup questionnaire was used to assess the amount and frequency of alcohol consumption.

The authors conclude that occasional or daily moderate drinking of alcoholic beverages (≤ 2 units per day), could reduce the risk of incident dementia compared to non-drinkers, with greater benefit for men with this level of daily consumption.


Liu Y, Mitsuhashi T, Yamakawa M, Sasai M, Tsuda T, Doi H, Hamada J, Alcohol consumption and incident dementia in older Japanese adults: The Okayama Study. Geriatr Gerontol Int. 2019 Jun 7. doi. org/10.1111/ggi.13694.

For more information about this article, read the scientific abstract here.


Cognitive decline is a common consequence of ageing. Alcohol consumption is a modifiable and plausible risk factor for age-related cognitive decline but more longitudinal studies investigating the association are needed.

The researchers assessed the relationship of self-reported adult-life weekly alcohol consumption and weekly extreme binge drinking with changes in test scores on an identical validated test of intelligence completed in early adulthood and late midlife. 2,498 Danish men from the Lifestyle and Cognition Follow-up study 2015 were included in the analysis. Binge drinking was defined as ≥10 units on the same occasion.

Men with adult-life alcohol consumption of more than 28 units/week had a larger decline in IQ scores from early adulthood to late midlife than men consuming 1–14 units/week (B29–35units/ week = −3.6; P < 0.001). Likewise, a 1-year increase in weekly extreme binge drinking was associated with a 0.12-point decline in IQ scores.

Adult-life heavy alcohol consumption and extreme binge drinking appear to be associated with larger cognitive decline in men. Moreover, extreme binge drinking may be more important than weekly alcohol consumption in relation to cognitive decline.


Grønkjær M, Flensborg-Madsen T, Osler M, Sørensen HJ, Becker U, Mortensen EL, Adult-life alcohol consumption and age-related cognitive decline from early adulthood to late midlife.. Alcohol and Alcoholism, agz038, alcalc/agz038

For more information about this article, read the scientific abstract here.

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