Thursday, 27 April 2023 14:52
A Dose-Dependent Association between Alcohol Consumption and Incidence of Proteinuria and Low Glomerular Filtration Rate: A Systematic Review and Meta-Analysis of Cohort Studies
By ebours
Previous cohort studies have reported conflicting associations between alcohol consumption and chronic kidney disease, characterized by proteinuria and low glomerular filtration rate (GFR). This systematic review, which included 14,634,940 participants from 11 cohort studies, assessed a dose-dependent association of alcohol consumption and incidence of proteinuria and low estimated GFR (eGFR) of <60 mL/min/1.73 m(2). Compared with non-drinkers, the incidence of proteinuria was lower in drinkers with alcohol consumption of =12.0 g/day (relative risk 0.87 [95% confidence interval 0.83, 0.92]), but higher in drinkers with alcohol consumption of 36.1-60.0 g/day (1.09 [1.03, 1.15]), suggesting a J-shaped association between alcohol consumption and the incidence of proteinuria. Incidence of low eGFR was lower in drinkers with alcohol consumption of =12.0 and 12.1-36.0 than in non-drinkers (=12.0, 12.1-36.0, and 36.1-60.0 g/day: 0.93 [0.90, 0.95], 0.82 [0.78, 0.86], and 0.89 [0.77, 1.03], respectively), suggesting that drinkers were at lower risk of low eGFR. In conclusion, compared with non-drinkers, mild drinkers were at lower risk of proteinuria and low eGFR, whereas heavy drinkers had a higher risk of proteinuria but a lower risk of low eGFR. The clinical impact of high alcohol consumption should be assessed in well-designed studies.
Published in
General Health
Tagged under
- Alcohol Consumption
- Humans
- Risk Factors
- Incidence
- Cohort Studies
- Glomerular Filtration Rate
- alcohol consumption
- Meta-Analysis
- Chronic kidney disease
- WIC AH
- WIC general health
- AH
- meta-analysis
- Meta-analysis
- Alcohol consumption
- Systematic review
- Risk factors
- Chronic Kidney Disease
- chronic kidney disease
- cohort study
- cohort studies
- Cohort study
- risk factors
- systematic review
- *Alcohol Drinking/adverse effects/epidemiology
- incidence
- Cohort studies
- *Proteinuria/epidemiology/etiology
- dose-dependent association
- proteinuria
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