Wednesday, 25 January 2023 19:16
A causal relationship between alcohol intake and type 2 diabetes mellitus: A two-sample Mendelian randomization study
By ebours
BACKGROUND AND AIMS: We investigated whether alcohol intake has a causal relationship with type 2 diabetes mellitus (T2DM) risk in adults of the Korean Genomic Epidemiology Study using two-sample Mendelian randomization (MR) analysis. METHODS AND RESULTS: Daily alcohol intake was calculated based on the type, average amount, and frequency of alcohol consumption for six months before the interview. The participants were divided into low- and high-alcohol intake of 20 g/day. After adjusting for the covariates related to T2DM, the independent genetic variants (instrumental variables) related to alcohol intake were explored by GWAS analysis in a city hospital-based cohort (n = 58,701). SNPs with a significant level of p-value
Additional Info
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Authors:
Liu, M.;Park, S.
- Issue: volume 32
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More Information:
For more information about this absctract, please contact
This email address is being protected from spambots. You need JavaScript enabled to view it. at the Deutsche Weinakademie GmbH
Published in
Diabetes
Tagged under
- Adult
- Alcohol
- Obesity
- Humans
- alcohol
- Polymorphism
- Genome-Wide Association Study
- Single Nucleotide
- type 2 diabetes
- WIC AH
- AH
- WIC diabetes
- polymorphism
- *Diabetes Mellitus
- adult
- obesity
- Type 2 diabetes
- *Mendelian Randomization Analysis
- Type 2/diagnosis/epidemiology/genetics
- Alcohol Drinking/adverse effects/epidemiology/genetics
- Fat intake
- Genetic variants
- Two-sample Mendelian randomization (MR)
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