Effect of Red Wine Consumption on Biomarkers of Oxidative Stress

AIMS: To evaluate the effect of acute and chronic consumption of red wine or de-alcoholized red wine with a similar antioxidant capacity on plasma total antioxidant capacity (TEAC), nuclear factor-kappaB (NF-kappaB) activity and F2-isoprostanes (8-iso-PGF(2alpha)) in healthy men.

METHODS: Nineteen healthy men with an increased waist circumference (>/=94 cm) and a body mass index above 25 kg/m(2) participated in a randomized, controlled crossover design trial. They daily consumed 450 ml of red wine (four drinks; 41.4 g alcohol) or 450 ml of de-alcoholized red wine during dinner for 4 weeks each. On the last day of each treatment period, blood was collected before and 1 h after a standardized dinner with red wine or de-alcoholized red wine and also 24-h urine was collected.

RESULTS: Absolute TEAC levels were higher 1 h after dinner with red wine compared with dinner with de-alcoholized red wine (1.3 versus 1.1 mmol Trolox equivalents/l; P = 0.03). Consumption of dinner together with de-alcoholized red wine acutely stimulated NF-kappaB activity in peripheral blood mononuclear cells (0.4-0.7 HeLa equivalents/2.5 mug protein; P = 0.006), whereas this increase was completely suppressed when the dinner was combined with red wine. A chronic increase in urinary 8-iso-PGF(2alpha) after 4 weeks of red wine consumption compared with de-alcoholized red wine consumption (157 pg/mg creatinine and 141 pg/mg creatinine, respectively, P = 0.006) was also observed.

CONCLUSIONS: Consumption of a moderate dose of red wine can acutely increase plasma TEAC and suppress NF-kappaB activation induced by a meal. Controversially, 4 weeks of red wine consumption compared with de-alcoholized red wine consumption increases the oxidative lipid damage marker 8-iso-PGF(2alpha).

Additional Info

  • Authors:

    Schrieks,I.C.; van den Berg,R.; Sierksma,A.; Beulens,J.W.; Vaes,W.H.; Hendriks,H.F.

  • Issue: Alcohol Alcohol / pages 153-9 / vol. 48 / issue 2
  • Published Date: 2012/8/2
  • More Information:

    For more information about this abstract, please contact
    This email address is being protected from spambots. You need JavaScript enabled to view it. at the Deutsche Weinakademie GmbH

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