26 June 2020 In Diabetes

BACKGROUND: This study aims to examine the association between alcohol consumption and the risk of pre- or type 2 diabetes mellitus (T2DM) by alcohol-induced flushing response in Korean male adults, particularly based on their body mass index (BMI).

METHODS: This study selected 1,030 (158 non-drinkers, 364 flushers, and 508 non-flushers) male adults who had medical checkups. A logistic regression analysis was used to compare the association between alcohol consumption and the risk of pre- or T2DM.

RESULTS: In both the normal-weight group (BMI /=23 kg/m(2) and 4 and 8 drinks: 2.42, 1.11-5.27). However, obese non-flushers had only a significant higher risk of pre- or T2DM when consuming more than 8 drinks of alcohol per week than the non-drinkers (2.72, 1.39-5.30).

CONCLUSION: These results suggest that obese flushers have an increased risk of developing pre- or T2DM even with less alcohol consumption.

27 February 2017 In Diabetes

AIMS/INTRODUCTION: Previous meta-analyses identified an inverse association of total alcohol consumption with the risk of type 2 diabetes. The current study further explored the relationship between specific types of alcoholic beverage and the incidence of type 2 diabetes.

MATERIALS AND METHODS: A search of PubMed, Embase and Cochrane Library databases from January 1966 to February 2016 was carried out for prospective cohort studies that assessed the effects of specific types of alcoholic beverage on the risk of type 2 diabetes. The pooled relative risks with 95% confidence interval were calculated using random- or fixed-effect models when appropriate.

RESULTS: A total of 13 prospective studies were included in this meta-analysis, with 397,296 study participants and 20,641 cases of type 2 diabetes. Relative to no or rare alcohol consumption, wine consumption was associated with a significant reduction of the risk of type 2 diabetes, with the pooled relative risks of 0.85, whereas beer or spirits consumption led to a slight trend of decreasing risk of type 2 diabetes (relative risk 0.96, 0.95, respectively). Further dose-response analysis showed a U-shaped relationship between all three alcohol types and type 2 diabetes. Additionally, the peak risk reduction emerged at 20-30 g/day for wine and beer, and at 7-15 g/day for spirits, with a decrease of 20, 9 and 5%, respectively.

CONCLUSIONS: Compared with beer or spirits, wine was associated with a more significant decreased risk of type 2 diabetes. The present study showed that wine might be more helpful for protection against type 2 diabetes than beer or spirits.

22 March 2016 In Diabetes

BACKGROUND: Patients with type 2 diabetes are prone to have obesity and dyslipidemia. The purpose of this study was to evaluate the usefulness of cardiometabolic index (CMI), a new index calculated as the product of waist-to-height ratio and triglycerides-to-HDL cholesterol ratio, for discrimination of diabetes.

METHODS: Subjects were 10,196 Japanese women and men who had received annual health checkups at their workplaces. Receiver-operating characteristic (ROC) analysis and logistic regression analysis were performed to determine relationships of CMI with hyperglycemia and diabetes.

RESULTS: In women and men, hemoglobin A1c was significantly higher in the highest quartile of CMI than in the other lower quartiles. By using ROC analysis, the cutoff values of CMI for hyperglycemia and diabetes were determined to be 0.799 and 0.800, respectively, in women and to be 1.625 and 1.748, respectively, in men. When these cutoff values were used in logistic regression analysis, there were strong associations of CMI with hyperglycemia and diabetes in women and men (odds ratio with 95% confidence interval of subjects with vs. subjects without high CMI: 6.98 [4.68-10.42] for hyperglycemia and 14.61 [5.95-35.88] for diabetes in women; 4.42 [3.66-5.35] for hyperglycemia and 5.38 [3.89-7.44] for diabetes in men).

CONCLUSION: The results suggest that CMI is a useful new index, reflecting both adiposity and blood lipids, for discrimination of diabetes.

06 May 2014 In Diabetes

AIMS/HYPOTHESIS: This systematic review examines the relationship between alcohol consumption and long-term complications of type 2 diabetes. Meta-analyses could only be performed for total mortality, mortality from CHD, and CHD incidence, because the availability of articles on other complications was too limited.

MATERIALS AND METHODS: A PubMed search through to September 2005 was performed and the reference lists of relevant articles examined. Among the relevant articles there were six cohort studies reporting on the risk of total mortality and/or fatal and/or incident CHD in alcohol non-consumers and in at least two groups of alcohol consumers.

RESULTS: Statistical pooling showed lower risks in alcohol consumers than in non-consumers (the reference category). The relative risk (RR) of total mortality was 0.64 (95% CI 0.49-0.82) in the or =18 g/day), the RRs of total mortality were not significant. Risks of fatal and total CHD were significantly lower in all three categories of alcohol consumers (<6, 6 to or =18 g/day) than in non-consumers, with RRs ranging from 0.34 to 0.75.

CONCLUSIONS/INTERPRETATION: This meta-analysis shows that, as with findings in the general population, moderate alcohol consumption is associated with a lower risk of mortality and CHD in type 2 diabetic populations.

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