Osteoporosis

 

Osteoporosis is a disease characterized by low bone mass and deterioration of bone tissue. This leads to increased bone fragility and risk of fracture (broken bones), particularly of the hip, spine, wrist and shoulder. It frequently goes undiagnosed until a fracture occurs, as there are no warning signs or symptoms, and adds to the burden of high health care costs.

Drinking a moderate amount of alcoholic beverages as part of a healthy lifestyle may benefit women’s bone health, lowering their risk of developing osteoporosis. Bones are in a constant state of remodelling with old bone being removed and replaced with new bone tissue. In individuals with osteoporosis, more bone is lost than reformed resulting in porous, weak bones. About 80% of all individuals with osteoporosis are women, and postmenopausal women face an even greater risk because estrogen, a hormone that helps to keep bone remodelling in balance, decreases after menopause. Several studies have shown that moderate drinkers have a higher bone density than non-drinkers or heavy drinkers, but these studies have provided no explanation for the differences in bone density. Researchers reported that the consumption of alcoholic beverages may raise estrogen synthesis or may behave similarly to estrogen by reducing bone turnover, but exactly how alcoholic beverages can reduce the risk of osteoporosis has not yet been clearly established.

 

The above summary provides an overview of the topic, for more details and specific questions, please refer to the articles in the database.

 

Background/Objectives:There is inconsistent evidence regarding the association between moderate alcohol consumption and bone mineral density (BMD). The aim of this study was to describe the associations between total and beverage-specific alcohol intake and bone loss in older men and women.Subject/Methods:A total of 862 randomly selected subjects (mean age 63 years, range 51-81, 51% men) were studied at baseline and 2 years later. BMD was assessed by dual-energy X-ray absorptiometry. Beverage specific and total alcohol intake was assessed by food-frequency questionnaire. Falls risk was determined using the short form Physiological Profile Assessment. Incident fractures were ascertained by questionnaire.Results:Total alcohol intake in men positively predicted change in BMD at the lumbar spine and hip (beta=0.008% and 0.006% per year per gram, P<0.05)…
OBJECTIVE: Epidemiological studies indicate that higher bone mass is associated with moderate alcohol consumption in postmenopausal women. However, the underlying cellular mechanisms responsible for the putative beneficial effects of alcohol on bone are unknown. Excessive bone turnover, combined with an imbalance whereby bone resorption exceeds bone formation, is the principal cause of postmenopausal bone loss. This study investigated the hypothesis that moderate alcohol intake attenuates bone turnover after menopause. METHODS: Bone mineral density was determined by dual-energy x-ray absorptiometry in 40 healthy postmenopausal women (mean +/- SE age, 56.3 +/- 0.5 y) who consumed alcohol at 19 +/- 1 g/day. Serum levels of the bone formation marker osteocalcin and the resorption marker C-terminal telopeptide (CTx) were measured by immunoassay at…
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The authors have taken reasonable care in ensuring the accuracy of the information herein at the time of publication and are not responsible for any errors or omissions. Read more on our disclaimer.