Low alcohol consumption and pregnancy and childhood outcomes: time to change guidelines indicating apparently 'safe' levels of alcohol during pregnancy? A systematic review and meta-analyses

OBJECTIVES: To determine the effects of low-to-moderate levels of maternal alcohol consumption in pregnancy on pregnancy and longer-term offspring outcomes.

SEARCH STRATEGY: Medline, Embase, Web of Science and Psych info from inception to 11 July 2016.

SELECTION CRITERIA: Prospective observational studies, negative control and quasi experimental studies of pregnant women estimating effects of light drinking in pregnancy (</=32 g/week) versus abstaining. Pregnancy outcomes such as birth weight and features of fetal alcohol syndrome were examined.

DATA COLLECTION AND ANALYSIS: One reviewer extracted data and another checked extracted data. Random effects meta-analyses were performed where applicable, and a narrative summary of findings was carried out otherwise.

MAIN RESULTS: 24 cohort and two quasi experimental studies were included. With the exception of birth size and gestational age, there was insufficient data to meta-analyse or make robust conclusions. Odds of small for gestational age (SGA) and preterm birth were higher for babies whose mothers consumed up to 32 g/week versus none, but estimates for preterm birth were also compatible with no association: summary OR 1.08, 95% CI (1.02 to 1.14), I2 0%, (seven studies, all estimates were adjusted) OR 1.10, 95% CI (0.95 to 1.28), I2 60%, (nine studies, includes one unadjusted estimates), respectively. The earliest time points of exposure were used in the analysis.

CONCLUSION: Evidence of the effects of drinking </=32 g/week in pregnancy is sparse. As there was some evidence that even light prenatal alcohol consumption is associated with being SGA and preterm delivery, guidance could advise abstention as a precautionary principle but should explain the paucity of evidence.

Additional Info

  • Authors:

    Mamluk,L.; Edwards,H.B.; Savovic,J.; Leach,V.; Jones,T.; Moore,T.H.M.; Ijaz,S.; Lewis,S.J.; Donovan,J.L.; Lawlor,D.; Smith,G.D.; Fraser,A.; Zuccolo,L.

  • Issue: BMJ Open. / pages e015410-
  • Published Date: 2017/8/3
  • More Information:

    For more information about this abstract, please contact
    This email address is being protected from spambots. You need JavaScript enabled to view it. at the Deutsche Weinakademie GmbH

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