Total and beverage-specific alcohol intake and the risk of aggressive prostate cancer: a case-control study

BACKGROUND: Ethanol in alcoholic beverages is a known carcinogen, but its association with aggressive prostate cancer (APC) is uncertain. Recent studies have shown a modest increase in risk of APC associated with heavy alcohol intake while association for beverage types remain inconsistent.

METHODS: Using a case-control design and self-administered questionnaire, we examined the association between APC (high grade and/or advanced stage) and frequency and quantity of alcohol intake 2 years prior to enrolment. Furthermore, we delineated the relationships for beverage-specific intakes of beer, red wine, white wine and spirits.

RESULTS: The study included 1282 APC cases and 951 controls. Beer intake frequency of 5 days per week was associated with increased risk compared with no beer intake (odds ratio=1.66, 95% confidence interval: 1.12-2.48) whereas wine was protective at all frequencies of consumption compared with those with no wine intake. For every 10 g per week ethanol intake from beer increase, the odds of advanced PC rose by 3% (OR=1.03, 95% CI: 1.02-1.05). No such increased risk was observed for red or white wine while a marginal dose-response relationship was found for spirits (OR=1.03, 95% CI: 0.99-1.07).

CONCLUSIONS: Heavy beer and possibly spirits consumption is associated with increased risk while no dose-response relationship was found for red or white wine. Wine drinkers at all frequencies have a decreased risk of APC compared with those who did not drink wine.Prostate Cancer and Prostatic Diseases advance online publication, 18 April 2017; doi:10.1038/pcan.2017.12

Additional Info

  • Authors:

    Papa,N.P.; Macinnis,R.J.; Jayasekara,H.; English,D.R.; Bolton,D.; Davis,I.D.; Lawrentschuk,N.; Millar,J.L.; Pedersen,J.; Severi,G.; Southey,M.C.; Hopper,J.L.; Giles,G.G.

  • Issue: Prostate Cancer Prostatic Dis. 2017 Apr 18. doi: 10.1038/pcan.2017.12. [Epub ahead of print]
  • Published Date: 2017/4/18
  • More Information:

    For more information about this abstract, please contact
    This email address is being protected from spambots. You need JavaScript enabled to view it. at the Deutsche Weinakademie GmbH

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